JAMA in this week published three articles about dietary fat in the etiological development of breast cancer, colon rectal cancer, and cardiovascular disease (CVD). Unexpectedly, all reported negative findings.
The Women’s Health Initiative (WHI) study is a randomized clinical trial in which about 49,000 healthy women with average age 62 were randomized into the intervention group or the comparison group, and were followed up on average 8 years. Women in the intervention group were instructed to adhere on a low fat diet (total fat accounted for 20% of total energy), while women in the comparison group could eat their usual diet (fat accounted for 30-35% of total energy).
